Research (Colorado Orthopaedic Research Institute)

Mission Statement

CORI’s mission is to encourage education, clinical and basic science research and to provide leadership in the field of orthopaedic surgery.

Who We Are:

Colorado Orthopaedic Research Institute is a full-service academic research organization providing extensive resources for physicians and PhDs to conduct clinical research in all specialties of medicine. Furthermore, CORI plans to provide a fellowship program in adult reconstruction, within the next 2 years, offering opportunities for medical research, subspecialty training, and international work with countries such as Norway.

Current Research Studies:

  • A Multicenter, Open-Label, Single-Arm, Proof of Concept Study of Pulsed Electromagnetic Field (PEMF) Therapy to Evaluate Synovial Fluid Markers in Subjects with Osteoarthritis of the Knee.
    • Sponsor: Regenesis Biomedical, Inc.
    • January 2016 – November 2016
  • The purpose of this study is to investigate the effect of PEMF treatment when administered twice daily over a 90-day period by looking at synovial fluid in subjects with osteoarthritis of the knee.

  • A Randomized, Sham-Controlled Pilot Study of Provant Therapy in the Treatment of Persistent Post-Operative Pain Following Total Knee Arthroplasty
    • Sponsor: Regenesis Biomedical, Inc.
    • April 2015 – February 2016
  • The purpose of this study is to investigate whether pulsed electromagnetic energy field (PEMF) therapy is effective in the treatment of persistent pain following total knee arthroplasty (TKA).

  • Cross-Sectional, Multi-Center Evaluation of 8 Year Metal Ion Trends for Pinnacle Metal Ion Trends for Pinnacle MoM System Used in Primary Hip Arthroplasty
    • Sponsor: DePuy Orthopaedics, Inc.
    • August 2013 – Present
  • The purpose of this clinical study is to evaluate blood metal ion levels as a function of time of implantation for the Pinnacle Acetabular MoM System.

Norwegian Colorado Research Visit: October 2014

After arriving in Denver, the Norwegian Contingent and the trip coordinator, Berit Kvalsvik Teige, Director of R&D/E&T at Helse Møre and Romsdal, traveled to Colorado Springs to attend a BBQ hosted by Dr. John and Candy Xenos. During this social introduction, the Norwegian guests had the opportunity to meet Susan Hicks, the CEO of Sky Ridge Medical Center; Douglas Kominksky, from University of Colorado; and Steve Schaefer, CEO of Health South Rehabilitation Hospital, among others who would collaborate during the Norwegians’ week itinerary.

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Monday morning the Norwegian visitors drove to Castle Rock Adventist hospital for an abounding schedule observing Dr. John Xenos perform a total knee arthroplasty and a total hip arthroplasty. Our guests enjoyed a tour of the Castle Rock Adventist hospital. Douglas Kominksky, from the University of Colorado, Denver/ Mucosal Inflammation Program, provided a presentation. They also received a presentation of the cutting edge, anesthesia protocols used by Dr. Xenos in joint replacements. Dr. Otto Husby, a Norwegian Orthopaedic Surgeon, presented a hip implant he designed and has been using in Norway, as well.

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Following the full Monday morning program, our guests traveled to the historic Brown Palace and had the evening to explore Denver and its Italian cuisine.

Tuesday, October 6th, marks a special day for the Norwegian visitors. They learned The Noble Prize for Physiology or Medicine was awarded to two Norwegians from their home area; thus the Dean of their medical school had to decline attending the trip, for understandable reasons!

The University of Colorado Anschutz Medical Campus planned an extensive visit for our group on Tuesday, led by Neil Krauss, Director of Administration. They received a private tour of the cardiology unit, the medical school anatomy lab, the cadaveric surgical facility, the surgical hardware tool shop, and the impressive, Medical Training Center patient assimilation lab. Throughout the morning, the group had the opportunity to meet with the Chancellor and Vice President of the medical school, cardiology and orthopaedic physicians, PhDs, and program directors, from a variety of departments. They learned about the fitness center and the associated dietary programs the University of Colorado is providing to improve the health knowledge and commitment in the surrounding community. During the meetings, the Norwegians presented their extensive HUNT Database, Orthopaedic data, and Hip Implant Data they have been collecting. Dr. Jennifer Steven Lapsley provided an exceptional wrap up for the day, by providing a tour of both the children’s gait lab and the Muscle Performance Laboratory followed by a presentation of her research collaboration interests.

Rita Erhmann, the Norwegian Consular, hosted a dinner downtown at The University Club of Denver for physicians, from the University of Colorado, Dr. Xenos, University of Colorado Medical School Directors, Orthopedic Biomechanic research engineers from Denver University, and other key research contributors to the week.

Denver University hosted the Norwegian guests on Wednesday morning. They presented the research projects they are currently pursuing and explored the options for designing effective research collaboration. Dr. Torstein Hole, Dr. Otto Husby, Dr. Vigdis Husby, and Dr. Øystein Lian each presented their research, including the HUNT database and orthopaedic database. Next they received an interactive tour of the Human Dynamics Laboratory Center, which synergistically uses radiography, EMG, force plates, high-speed cameras, and motion plates to obtain joint and bone data. They learned about the high-speed stereo radiographic system at Denver University, which has the capacity to capture bi-plane radiographs. Although no one in the group underwent imaging, Dr. Torstein Hole put on markers and moved on the motion plates to demonstrate how the system can observe movement and forces. The group reconvened for a wrap up meeting at lunch, before leaving for Vail

The Steadman Philippon Research Institute hosted a tour and presentation Thursday morning, while some of the Norwegian surgeons went to observe surgeries with one of their Norwegian colleagues, a physician who is presently visiting Steadman Clinic for an extending time. The other members of the group had a formal introduction to the research institute and the achievements of the small, yet exceptional Steadman research team, including their engineers, PhDs, and Dr. Charles Ho, Director of Imaging Research. Following the presentation, there was a tour of the BioMotion Laboratory, which they use extensively for observing movement and impact on the joints of athletes in sports, such as hockey, skiing, basketball, tennis etc. The Institute’s biplane fluoroscopy and motion capture technology provided the blueprint for the advanced radiographic imaging design at Denver University. The research team has a biomechanical tool shop, designated only for their research, in the vicinity of their BioMotion Lab. On the tour of the Biomechanical Testing laboratory, they introduced the Norwegians to “Rosy” the robot, who was currently applying different angles and weight to a cadaveric hip to demonstrate the motion and pressure that results in hip fractures and other stress. They also have a surgical skills cadaveric lab, which enamored the Norwegian visitors who have not had the opportunity to implement this practice into their medical training. The Norwegians hosted a lunch for the Steadman researcher team and then planned for the evening with Gary Peterson, CEO of the Steadman Clinic. Over the course of dinner, a meeting with the CEO for Friday morning was arranged to discuss research collaboration in greater detail and to brainstorm project ideas. Dr. Laprade came to make the final presentation and farewell.

Overall, the Norwegian visit was a resounding success! We look forward to our future collaboration


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